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Exosomes Grand Cayman

Conveniently located on Seven Mile Beach, Grand Cayman

Exosome therapy utilizes exosomes (small sacs that contain cells) to counter the effects of aging. Exosomes are secreted by most cells in the body and are involved in a broad range of important cellular processes. When administered to the target body area, exosomes stimulate collagen production, generate additional healing cells, and accelerate recovery from various types of injury and disease.

 

Are you considering a non-surgical method of counteracting the effects of aging on the body? Consider a visit to Nurse Kelly to achieve a younger skin profile and treat various medical conditions. Call  1 (345) 943-6363   to learn more about exosome therapy or book an appointment online. We are located at West Shore Center (Pink Plaza), 508 West Bay Road, PO Box 32078, Grand Cayman KY1-1208, Cayman Islands, B.W.I.

 

Schedule a consultation with one of our highly trained and experienced practitioners at Cayman Doctors now to gain more understanding about exosome therapy.

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Contents

Fast Facts

Who’s it for?

Exosome therapy is indicated for patients with fine lines and wrinkles, different types of wounds, hair loss, and urinary incontinence.

 

Similar products:

Stem cell therapy

 

Celebs who swear by it:

Kourtney Kardashian, Sarah Hyland and Sofia Vergara

What is Exosome Therapy?

Exosomes are small sacs that contain cells and are involved in regulating cellular communication to ensure optimal body function. Most cells secrete exosomes to carry out vital cellular processes. For instance, exosomes transmit valuable lipids, proteins, DNA, and RNA. Exosomes can also be used to carry drugs to target specific body cells or tissues. When administered via injections to the target body area, they can help revitalize cells and improve overall health by improving cellular communication. Since exosomes contain a significant amount of growth factors, they can help fight signs of aging and treat certain medical conditions.

How Exosome Therapy Works

This form of regenerative medicine works by enhancing cellular communication. As a result, the body heals itself through increased cell turnover, a process in which new, healthy cells replace the old, damaged cells. The significant amount of growth factors in exosomes also helps repair damaged tissues and organs in the body, resulting in improved overall health.

 

Advantages of Exosome Therapy

Exosome with Nurse Kelly in Grand Cayman has the following advantages:

 

  • Shorter recovery time: The procedure is minimally invasive and does not require surgery, allowing you to return to your normal routine afterward.
  • Minimal discomfort: The treatment is applied after certain procedures as an add-on or it can be directly injected into the target area with the use of numbing creams.
  • Quick procedure: Depending on the condition being treated, the entire process can take anywhere from 30 to 60 minutes to complete.
  • Numerous indications: This regenerative treatment can help address signs of aging, different types of wounds, hair loss, and urinary incontinence.
Women laying down with a towel wrapped around her head in a spa like environment Doctors office with a mid 20 years old with the doctor in the background

Risks and Complications of Exosome Therapy

Like any form of regenerative treatment, exosome therapy also has risks and complications such as:

 

  • Failure of the cells to achieve their desired effects
  • Infection
  • Injection site reactions
  • Potential contamination of the product

 

Nurse Kelly works to ensure that Exosome therapy is safe and effective. During your consultation with one of our highly trained and experienced practitioners at Cayman Doctors, your overall health will be thoroughly assessed to lower the risk of complications.

What to Expect before Exosome Therapy

Before the treatment, Nurse Kelly will provide specific instructions to ensure the best clinical outcomes. These include the following:

 

  • Avoid caffeine and alcohol.
  • Avoid smoking.
  • Avoid taking blood-thinning medications, supplements, or herbs.
  • Undergo certain medical tests.

What to Expect during Exosome Therapy

Depending on the condition being treated, exosomes can be administered topically or injected. Before the treatment, a numbing cream will be applied to minimize discomfort associated with the injection process. The exosomes will be then administered and you will be assessed thoroughly for any reaction to the treatment. The dosing of exosomes may vary from patient to patient.

Exosome Therapy Recovery Time

The treatment is usually performed on an outpatient basis so you will be allowed to go home afterwards. You may experience some redness or mild swelling at the injection site but they can be easily managed by applying ice packs. They usually resolve within 24 hours. To determine if additional treatments are necessary, you will need to follow up with Nurse Kelly.

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Conditions Treated by Exosome Therapy

Exosome therapy can help address signs of aging and certain medical conditions. The anti-aging and regenerative properties of this treatment are backed by a convincing number of studies.

Fine Lines and Wrinkles

Fine lines and wrinkles are the most common signs of skin aging. They are caused by the age-related decline in the production of collagen, a protein that is essential for the maintenance of skin elasticity and structures. Exosome therapy significantly increases the production of collagen to achieve tighter, firmer, and younger-looking skin.

 

A study isolated exosomes from human adipose-derived stem cells (ADSCs) to determine if they can alleviate the senescence of human dermal fibroblasts (active skin replacement cells). [1] Results showed that the ADSC-derived exosomes increased the production of type I collagen and reduced the levels of reactive oxygen species (free radicals). Moreover, ADSC-derived exosomes significantly reduced the levels of proteins that cause senescence in human dermal fibroblasts.

 

A study investigated the effects of exosomes derived from human dermal fibroblast in a mouse model of photoaging (premature skin aging due to sun exposure). [2] A needle-free injector was used to administer the exosomes to the subjects. After the treatment, the subjects had increased levels of procollagen type I and transforming growth factor beta (TGF-β). In addition, a decrease in tumor necrosis factor-alpha (a substance that triggers skin inflammation) was observed.

 

The effects of topical (skin) application of exosomes derived from human umbilical cord mesenchymal stem cells combined with marine sponge Haliclona sp. spicules were investigated in mice with ultraviolet-induced photoaging. [3] Skin changes were analyzed using a special device. Results showed that the combined treatment reduced microwrinkles and alleviated skin changes induced by photoaging.

 

Treatment Options

Exosome therapy stimulates the production of collagen and growth factors to reduce the signs of skin aging.

Different Types of Wounds

Whether they are caused by trauma, injury, or an underlying medical condition, wounds can increase the risk of infection. Moreover, unsightly scars may form even when wounds heal completely. Aside from cosmetic concerns, abnormal wound healing can lead to raised or thick scars that can cause unpleasant symptoms such as pain or itching.

 

Exosome therapy can help accelerate the healing of different wound types through various mechanisms. These include increasing collagen production, boosting the release of growth factors, promoting the formation of new blood vessels, and reducing the levels of inflammatory substances. As a result, wounds heal normally and abnormal scarring can be prevented.

 

The effects of selenium-stimulated exosomes on human umbilical vein endothelial cells were evaluated. [4] It was found that selenium-stimulated exosomes significantly inhibited inflammation and improved the formation of new blood vessels. In addition, selenium-stimulated exosomes enhanced cell growth and migration of human dermal fibroblasts (active skin replacement cells) which in turn promoted faster wound regeneration.

 

The wound-healing properties of exosomes from human adipose-derived mesenchymal stem cells were evaluated in a diabetic mouse model. [5] A 1.5 cm2 full-thickness cutaneous wound was made in female diabetic mice. The mice were then treated with exosomes from human adipose-derived mesenchymal stem cells three times a day for 2 weeks. After the treatment period, it was found that the mice exhibited enhanced skin collagen production, angiogenesis (formation of new blood vessels), and cell proliferation. Moreover, the treatment also inhibited apoptosis (programmed cell death), promoted the repair of skin barrier function, and reduced skin lesion inflammation.

 

A study evaluated the wound-healing effects of exosomes derived from adipose stem cells. [6] The study included mice with diabetic wounds. The wounds were then treated with exosomes derived from adipose stem cells, exosomes derived from dermal fibroblasts, or phosphate-buffered saline. Results showed that the exosomes derived from adipose stem cells promoted the migration of cells necessary for wound healing at the site of injury and stimulated the formation of new blood vessels. The wound-healing effects of exosomes derived from adipose stem cells are more potent than exosomes derived from dermal fibroblasts and phosphate-buffered saline.

 

Treatment Options

Exosome therapy speeds up wound healing by boosting collagen production, promoting the formation of new blood vessels, and reducing inflammation.

Hair Loss

Several factors such as aging, medications, and certain medical conditions can lead to hair loss. This in turn can affect your self-esteem as well as your quality of life. Exosome therapy can help stimulate hair regeneration by prolonging the hair growth cycle known as the anagen phase. Over time, you can achieve stronger, fuller, and healthier hair.

 

A study investigated the effects of exosomes from adipose-derived stem cells on hair dermal papilla cells (specialized cells involved in hair formation, growth, and cycling). [7] A hair-depilated mouse model received subcutaneous (fatty tissue) injections of exosomes from adipose-derived stem cells. Results showed that the treatment significantly promoted hair dermal papilla cell proliferation and migration while also reducing cell death. In addition, the treatment also resulted in better hair growth, more hair follicles, and thicker dermis (middle skin layer).

 

A study evaluated the effects of exosomes derived from bovine colostrum (milk exosomes) in mice with hair loss. [8] It was found that the treatment promoted hair dermal papilla cell proliferation and hair follicle development by protecting against dihydrotestosterone-induced cell cycle arrest. In addition, the treatment also induced hair regrowth in mice by accelerating the hair cycle transition from telogen (resting stage) to the anagen phase.

 

A study compared the effects of dermal exosomes containing miR-218-5p and minoxidil (a medication for hair loss) in hair-depilated mice. [9] Results revealed that dermal exosomes containing miR-218-5p were effective at inducing the progression of the hair follicle cycle from telogen to anagen phase compared with minoxidil treatment. Moreover, it was found that dermal exosomes containing miR-218-5p exerted their hair regeneration effects by regulating β-catenin signalling, which is involved in hair follicle regeneration and growth.

 

Treatment Options

Exosome therapy promotes hair regeneration by prolonging the hair growth phase and protecting against hair cell death.

Question & Answer

Are there discomforts associated with exosome therapy?

You may experience some redness or mild swelling at the injection site but they can be easily managed by applying ice packs. They usually resolve within 24 hours.

How long does it take to see exosome therapy results?

You may begin to see the results of the treatment after 2-3 months. The final results will be noticeable after 6 months.

How many treatments will I need?

Most patients experience the benefits of exosome therapy after just one treatment. However, additional treatments may be prescribed depending on the condition being treated.

Who are the ideal candidates for exosome therapy?

As long as you are in good overall physical and mental health, the treatment is right for you.

How much does exosome therapy cost?

The total cost will depend on the following factors:

  • The practitioner’s fee
  • The fee of the clinic or medical facility
  • The number of treatment sessions required
  • The body area needing treatment

References

  1. Guo, J. A., Yu, P. J., Yang, D. Q., & Chen, W. (2022). The Antisenescence Effect of Exosomes from Human Adipose-Derived Stem Cells on Skin Fibroblasts. BioMed research international, 2022, 1034316. https://doi.org/10.1155/2022/1034316. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259368/.
  2. Hu, S., Li, Z., Cores, J., Huang, K., Su, T., Dinh, P. U., & Cheng, K. (2019). Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging. ACS nano, 13(10), 11273–11282. https://doi.org/10.1021/acsnano.9b04384. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032013/.
  3. Zhang, K., Yu, L., Li, F. R., Li, X., Wang, Z., Zou, X., Zhang, C., Lv, K., Zhou, B., Mitragotri, S., & Chen, M. (2020). Topical Application of Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells in Combination with Sponge Spicules for Treatment of Photoaging. International journal of nanomedicine, 15, 2859–2872. https://doi.org/10.2147/IJN.S249751. Retrieved from https://pubmed.ncbi.nlm.nih.gov/32368058/.
  4. Heo J. S. (2022). Selenium-Stimulated Exosomes Enhance Wound Healing by Modulating Inflammation and Angiogenesis. International journal of molecular sciences, 23(19), 11543. https://doi.org/10.3390/ijms231911543. Retrieved from https://pubmed.ncbi.nlm.nih.gov/36232844/.
  5. Zhao, B., Zhang, X., Zhang, Y., Lu, Y., Zhang, W., Lu, S., Fu, Y., Zhou, Y., Zhang, J., & Zhang, J. (2021). Human Exosomes Accelerate Cutaneous Wound Healing by Promoting Collagen Synthesis in a Diabetic Mouse Model. Stem cells and development, 30(18), 922–933. https://doi.org/10.1089/scd.2021.0100. Retrieved from https://pubmed.ncbi.nlm.nih.gov/34167333/.
  6. Hsu, H. H., Wang, A. Y. L., Loh, C. Y. Y., Pai, A. A., & Kao, H. K. (2022). Therapeutic Potential of Exosomes Derived from Diabetic Adipose Stem Cells in Cutaneous Wound Healing of db/db Mice. Pharmaceutics, 14(6), 1206. https://doi.org/10.3390/pharmaceutics14061206. Retrieved from https://pubmed.ncbi.nlm.nih.gov/35745779/.
  7. Li, Y., Wang, G., Wang, Q., Zhang, Y., Cui, L., & Huang, X. (2022). Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia. Journal of immunology research, 2022, 7471246. https://doi.org/10.1155/2022/7471246. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831060/.
  8. Kim, H., Jang, Y., Kim, E. H., Jang, H., Cho, H., Han, G., Song, H. K., Kim, S. H., & Yang, Y. (2022). Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition From Telogen to Anagen Phase. Frontiers in cell and developmental biology, 10, 815205. https://doi.org/10.3389/fcell.2022.815205. Retrieved https://pubmed.ncbi.nlm.nih.gov/35359449/.
  9. Hu, S., Li, Z., Lutz, H., Huang, K., Su, T., Cores, J., Dinh, P. C., & Cheng, K. (2020). Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling. Science advances, 6(30), eaba1685. https://doi.org/10.1126/sciadv.aba1685. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439409/.
  10. Ni, J., Li, H., Zhou, Y., Gu, B., Xu, Y., Fu, Q., Peng, X., Cao, N., Fu, Q., Jin, M., Sun, G., Wang, J., Jin, Y., & Liu, F. (2018). Therapeutic Potential of Human Adipose-Derived Stem Cell Exosomes in Stress Urinary Incontinence – An in Vitro and in Vivo Study. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 48(4), 1710–1722. https://doi.org/10.1159/000492298. Retrieved from https://pubmed.ncbi.nlm.nih.gov/30077997/.
  11. Wu, R., Huang, C., Wu, Q., Jia, X., Liu, M., Xue, Z., Qiu, Y., Niu, X., & Wang, Y. (2019). Exosomes secreted by urine-derived stem cells improve stress urinary incontinence by promoting repair of pubococcygeus muscle injury in rats. Stem cell research & therapy, 10(1), 80. https://doi.org/10.1186/s13287-019-1182-4. Retrieved from https://pubmed.ncbi.nlm.nih.gov/30849996/.
  12. Rolland, T. J., Peterson, T. E., Singh, R. D., Rizzo, S. A., Boroumand, S., Shi, A., Witt, T. A., Nagel, M., Kisby, C. K., Park, S., Rowe, L. A., Paradise, C. R., Becher, L. R. E., Paradise, B. D., Stalboerger, P. G., Trabuco, E. C., & Behfar, A. (2022). Exosome biopotentiated hydrogel restores damaged skeletal muscle in a porcine model of stress urinary incontinence. NPJ Regenerative medicine, 7(1), 58. https://doi.org/10.1038/s41536-022-00240-9. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523025/.